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Bulk 98% Huperzine A Powder 120786-18-7
Introduction and characteristics of Huperzine A
Product Introduction
Huperzine A is a natural alkaloid that can be isolated from Huperzine serrata of the Huperzaceae family. It is a potent, highly specific, and reversible acetylcholinesterase inhibitor. It is almost insoluble in water and is now mostly used in myasthenia gravis and benign memory disorders. It also has a certain effect on AD and senile memory impairment.
Features
● Natural source: It is a new chemical substance with significant acetylcholinesterase inhibitory effect discovered from the fern medicinal plant "Snake Foot Grass".
● Strong ability to penetrate the blood-brain barrier: small molecules, high fat solubility, easy to pass through the blood-brain barrier into the central nervous system, with both central and peripheral therapeutic effects, and can be more distributed in the frontal lobe, temporal lobe, hippocampus and other brain areas closely related to learning and memory.
● Good absorption: good absorption from the gastrointestinal tract, rapid and complete oral absorption, high bioavailability.
● Good stability: stable at room temperature, not easy to decompose and deteriorate.
Function of Huperzine A
Improve cognitive function
By inhibiting the activity of acetylcholinesterase, reducing the decomposition of acetylcholine, and increasing the level of acetylcholine in the central nervous system, it helps to improve the efficiency of information transmission between brain cells, and has a regulating effect on symptoms such as inattention and slow thinking caused by decreased function of the cholinergic system.
Treatment of memory impairment
It can enhance the plasticity of synapses in the hippocampus and promote the transformation of short-term memory to long-term memory. Clinical studies have shown that for vascular cognitive impairment, memory loss after brain trauma and other diseases, rehabilitation training can improve memory test scores.
Relieve dementia symptoms
For patients with early Alzheimer's disease, it can slow down the decline of cognitive function. Its mechanism of action includes inhibiting the deposition of amyloid beta protein and the hyperphosphorylation of tau protein, but it needs to be combined with drugs such as donepezil for treatment.
Regulate neurotransmitter balance
In addition to affecting the cholinergic system, it also has a regulatory effect on the glutamatergic system and can reduce excitatory neurotoxicity. This dual regulatory property makes it play an auxiliary role in the treatment of Parkinson's disease-related cognitive impairment.
Anti-oxidative stress
It can scavenge oxygen free radicals, enhance superoxide dismutase activity, and reduce oxidative damage to brain tissue. Animal experiments have shown that it can reduce neuronal apoptosis caused by ischemia-reperfusion injury, but it has limited improvement on organic lesions that have already formed.
Improve symptoms of myasthenia gravis
It can effectively improve the muscle strength and tension of myasthenia gravis patients, improve the limb function of patients, and improve the quality of life. Its therapeutic mechanism may be related to increasing the content of acetylcholine in the central nervous system and improving the signal transmission between synapses.
How does Huperzine A improve cognitive function?
Inhibit acetylcholinesterase
Huperzine A is a reversible acetylcholinesterase inhibitor that can inhibit the activity of acetylcholinesterase in the brain, reduce the decomposition of acetylcholine, and thus increase the concentration of acetylcholine in the synaptic cleft. Acetylcholine is an important neurotransmitter involved in memory and cognitive function. Its increased level helps improve patients' attention, orientation, and logical thinking ability, thereby improving cognitive function.
Regulate neurotransmitter balance
It can regulate the balance of multiple neurotransmitters in the brain, such as promoting the release of dopamine and serotonin, while inhibiting neurotoxicity caused by excessive glutamate excitation. This dual regulatory effect helps maintain the functional stability of the neuronal network and plays a positive role in improving cognitive function.
Improve learning and memory ability
By enhancing synaptic plasticity in the hippocampus and promoting long-term potentiation, it can improve information encoding and storage functions. Clinical trials have shown that it can improve word recall and pattern recognition in patients with mild to moderate cognitive impairment, thereby improving overall cognitive levels.
Alleviate mild cognitive impairment
For age-related memory loss or early cognitive impairment, Huperzine A can alleviate symptoms such as forgetfulness and slow response by improving cerebral blood flow and energy metabolism. Its mechanism of action involves regulating glucose utilization and mitochondrial function in the brain, which helps maintain normal brain function and improve cognitive status.
Application of Huperzine A
Food
Natural preservatives: Apigenin has antibacterial effects and can be used as a natural preservative in meat products, fruits, frozen foods, etc., effectively inhibiting microbial reproduction and extending the shelf life of food.
Functional foods: As a food additive, apigenin is used to develop functional foods with health-promoting functions, such as beverages and snacks rich in antioxidants.
Cosmetics
Whitening and anti-aging: Apigenin can inhibit the formation of melanin, promote the metabolism of skin cells, achieve whitening and anti-aging effects, and is used to develop whitening and anti-aging cosmetics.
Sunscreen: It has a strong ability to absorb ultraviolet rays and can be used in sunscreen cosmetics to protect the skin from ultraviolet damage.
Health products
Dietary supplements: As a natural compound, apigenin is made into dietary supplements for people to supplement the insufficient nutrients in their daily diet and enhance their health.
Health promotion: Its antioxidant and anti-inflammatory properties help prevent chronic diseases, improve immunity, and promote overall health.
