Sophora Japonica Extract Kaempferol 98% Powder

Kaempferol (Kae) is a well-defined natural polyphenol and one of the most common dietary flavonoids, widely found in various plant-based foods. Research indicates that kaempferol exhibits significant neuroprotective effects in a variety of neurological diseases. Its mechanisms primarily involve anti-inflammatory effects and the reduction of oxidative stress mediated by microglial cell activation. It can effectively scavenge excess superoxide free radicals in the body, thus preventing DNA and cellular oxidative damage. In addition, kaempferol also possesses a range of pharmacological activities, including anti-inflammatory, anti-aging, anti-diabetic, and osteoporosis treatment effects.

● Inhibits NADPH or Fe²⁺-induced lipid peroxidation, scavenges superoxide anions, and alleviates oxidative stress.

● Regulates the expression of antioxidant enzymes (such as catalase, glutathione peroxidase, and glutathione-S-transferase), relieving liver oxidative damage caused by alcohol and polyunsaturated fatty acids.

● Activates heme oxygenase-1 (HO-1), inhibits the production of iNOS and NO, protecting macrophages from lipopolysaccharide-induced damage.

● Inhibits LPS-induced MAPK signaling pathway in THP-1 monocytes, reducing the release of inflammatory factors (MDC, IP-10, IL-8).

● Reduces oxidative stress-induced neural damage and protects SHSY5Y neuroblastoma cells from rotenone toxicity.

● Decreases ROS levels and mitochondrial hydroxyl compound content, inhibits cell apoptosis, showing potential neuroprotective value.

● Significantly inhibits the activity of protein kinase CK2, with effects superior to known inhibitors (e.g., 4-bromo-2-azabenzimidazole).

● Inhibits CHOP protein expression, reducing endoplasmic reticulum stress-induced hepatocyte apoptosis.

● As a major component of liver-protective pills, it is used in Asia for the prevention and treatment of liver diseases.

● Upregulates Bcl-2 through the SIRT1-mediated mitochondrial pathway, alleviating cardiomyocyte apoptosis caused by hypoxia/reoxygenation (A/R) injury.

● Enhances glucose uptake in 3T3-L1 adipocytes, improving insulin sensitivity.

● Lowers blood sugar, regulates blood lipids, and delays the complications of type 2 diabetes through antioxidant, anti-inflammatory, and aldose reductase inhibition pathways.

● Activates estrogen receptors, promoting proliferation, differentiation, and mineralization of osteoblasts.

● Increases bone mineral density in ovariectomized rats, reduces bone calcium and phosphorus loss, and inhibits bone resorption-related enzymes (such as tartrate-resistant acid phosphatase and cathepsin K).

● Micro-CT analysis shows improvement in trabecular bone structure, indicating potential anti-osteoporosis benefits.

● Antimicrobial: Inhibits pathogenic bacteria, including Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhi, and Shigella dysenteriae.

● Other effects: Cough suppression, anti-cataract, contraception, anti-epileptic, and antispasmodic activities.