Factory Supply 98% Nicotinamide Riboside NR Powder

Nicotinamide riboside (NR) is an important precursor of nicotinamide adenine dinucleotide (NAD+), also known as Coenzyme I, and is considered a form of vitamin B3. NAD+ is a coenzyme that plays a key role in cellular metabolism, participating in the breakdown of compounds like proteins, carbohydrates, and fats. It is an essential substance for life activities in the human body. As cells age or undergo pathological changes, the levels of NAD+ gradually decrease. Therefore, supplementing nicotinamide riboside can increase NAD+ levels, enhance basic cellular metabolic activities, significantly improve cell vitality, and improve various physiological functions of the body.

NAD+ has many important functions within human cells, including providing energy for metabolism, synthesizing new cellular components, combating free radicals, repairing DNA damage, and participating in cellular signaling. Mitochondria, known as the "powerhouses" of cells, convert food into energy required by the body, maintaining various functions. Additionally, NAD+ can delay the aging process by regulating gene expression. Therefore, NAD+ is crucial for life activities, and nicotinamide riboside, as its precursor, holds significant value in maintaining health and delaying aging.

Nicotinamide Riboside (NR): A Promising NAD+ Precursor Supplement

Nicotinamide riboside (NR), as an emerging NAD+ precursor supplement, has garnered significant attention in recent years. Two key studies have revealed the profound effects of NR supplementation on the human body, offering exciting findings from the brain to the whole body.

Research Findings

1. NR Supplementation Significantly Increases Brain NAD+ Levels

The results show that after NR supplementation, the average NAD+ concentration in the participants' brains was significantly higher than baseline levels (0.458 ± 0.053 vs. 0.392 ± 0.058 mM; p < 0.001). All participants showed an increase in NAD+ levels after NR supplementation, with increases ranging from 7% to 40%. On average, brain NAD+ levels increased by 0.065 mM (approximately 16%) after NR supplementation.

2. Baseline NAD+ Levels Remain Stable

To assess the test-retest reliability of brain NAD+ signals, the study conducted two additional scans on the same group of volunteers without NR supplementation. The average NAD+ concentrations for these two baseline scans were 0.425 ± 0.118 mM and 0.405 ± 0.082 mM, with no significant difference between them (p = 0.45). NAD+ concentrations remained consistent across the three baseline scans (F(2, 16) = 0.907; p = 0.424).

3. NAD+ Measurement Shows Good Reproducibility

Moderate reliability was observed between scans 3 and 4 (ICC = 0.73, 95% CI: 0.21, 0.93), and the three baseline scans also showed good reproducibility (ICC = 0.66, 95% CI: 0.29, 0.90). This indicates that the DF 1H MRS technique for measuring brain NAD+ levels is highly reliable and consistent.

4. NR Supplementation is Well-Tolerated

NR supplementation showed good tolerability among participants. Reported side effects included muscle pain, gastrointestinal irritation, sweating, nausea, and headaches, but the common skin flushing associated with niacin was not observed. Safety parameters in blood samples (such as kidney function markers, liver enzymes, and full blood counts) remained stable without any abnormal changes.

NR supplementation not only significantly increases brain NAD+ levels but also demonstrates good safety and tolerability. These findings provide scientific support for the potential use of NR in improving brain health and delaying aging, while laying the groundwork for future research on the relationship between NAD+ and human health.

Nicotinamide riboside chloride is the crystalline form of nicotinamide riboside (NR), which is generally regarded as safe (GRAS) and can be used in food and dietary supplements. Nicotinamide riboside is a source of vitamin B3 (niacin) that enhances oxidative metabolism and prevents metabolic abnormalities caused by high-fat diets. As a newly discovered NAD+ (nicotinamide adenine dinucleotide) precursor vitamin, nicotinamide riboside plays an important role in increasing tissue NAD+ levels, enhancing insulin sensitivity, and activating sirtuin functions.

Its ability to increase NAD+ production suggests that nicotinamide riboside can also improve mitochondrial health, stimulate mitochondrial function, and promote the generation of new mitochondria. Furthermore, studies in Alzheimer’s disease models have shown that nicotinamide riboside is bioavailable in the brain, offering neuroprotective effects by stimulating NAD+ synthesis in the brain. These findings further highlight the potential value of nicotinamide riboside in improving metabolic health, delaying aging, and supporting neurological function.