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Alpha Mangostin Powder CAS 6147-11-1
What is Alpha Mangostin?
Alpha Mangostin is a naturally occurring compound with significant biological activity. It appears as a yellow powder and is insoluble in water but soluble in non-polar to moderately polar organic solvents such as n-hexane and chloroform. As an active ingredient derived from the mangosteen fruit, it has a long history of safe consumption, which provides a solid foundation for its in-depth research and application in the pharmaceutical field. From a bioactivity perspective, α-mangostin exhibits a wide range of pharmacological effects, including notable antioxidant, anti-inflammatory, and antiviral properties. Moreover, it has been identified as a specific inhibitor of mutant IDH1, highlighting its unique potential in treating related diseases.
In terms of industrial production, α-mangostin is primarily extracted from mangosteen pericarps. However, the crude extract often contains structurally similar compounds such as β-mangostin and γ-mangostin, which pose significant challenges for subsequent purification processes. Although a combination of natural extraction and recrystallization techniques can yield high-purity products, meeting pharmaceutical-grade purity standards of 95%–99.9% still involves complex procedures and high production costs. These technical and economic limitations currently hinder the large-scale application of α-mangostin in advanced pharmaceutical fields, prompting ongoing research into more efficient separation and purification methods.
Health Benefits of α-Mangostin
As a natural compound with multiple biological activities, α-mangostin demonstrates significant medical value in areas such as anti-inflammation, gastrointestinal protection, and neurological health.
Anti-Inflammatory and Analgesic Effects
α-Mangostin effectively inhibits inflammatory responses, helping to reduce symptoms such as swelling and pain, making it suitable for alleviating various inflammatory conditions.
Gastrointestinal Protection and Anti-Ulcer Effects
This compound promotes the repair and regeneration of gastric mucosa, aiding in the treatment of digestive system disorders like gastric ulcers and contributing to overall gastrointestinal health.
Neuroprotection and Brain Health
α-Mangostin offers multi-target protective effects in the prevention and treatment of neurological disorders, including:
● Inhibiting inflammation to reduce neural damage;
● Combating oxidative stress to delay neurodegeneration;
● Preventing neuronal apoptosis to preserve brain function.
These mechanisms suggest that α-mangostin holds promising therapeutic potential in neurodegenerative and psychiatric disorders such as Alzheimer’s disease, Parkinson’s disease, depression, and vascular dementia.
Multifaceted Application Prospects of Alpha Mangostin powder
Agricultural Field: Green Antibacterial Agent
In crop protection, α-mangostin has demonstrated remarkable antibacterial properties, showing strong inhibitory effects against common plant diseases such as bacterial blight in rice and bacterial fruit blotch in melon. This makes it a promising candidate for the development of new plant-based antibacterial agents and presents an important direction for future research.
Chemical and Pharmaceutical Fields: Cardiovascular Disease Prevention and Treatment
In drug development, α-mangostin can serve as a key active ingredient in the formulation of novel medications aimed at preventing and treating hypertension and its complications, such as hypertensive nephropathy. This application not only expands its value in chemical synthesis but also provides innovative solutions for managing cardiovascular diseases.
With its unique bioactivity and versatile applications, α-mangostin is becoming a focal point of interdisciplinary research and is expected to achieve breakthrough applications in an increasing number of fields in the future.
