Wholesale 99% Tauroursodeoxycholic Acid Powder CAS 14605-22-2
What is tauroursodeoxycholic acid(TUDCA?)
Tauroursodeoxycholic acid, commonly referred to as TUDCA, is a water-soluble (hydrophilic) bile acid found in large quantities in bear bile and is the primary component of synthetic bear bile. It is a conjugated bile acid widely found in the bile of humans and various animals and has multiple physiological and pharmacological effects. It exhibits significant hepatoprotective properties, including reducing oxidative stress, inhibiting apoptosis, and alleviating inflammation, thereby promoting liver cell repair and regeneration.
Why Choose YTBIO Tauroursodeoxycholic Acid (TUDCA)？
We have over 12 years of experience supplying high-purity bile acid active ingredients for liver protection supplements, gallbladder wellness, eye health and anti-aging research. Our workshop is certified with cGMP, FSSC22000, HACCP, HALAL, KOSHER, ISO9001 & ISO22000, compliant with global dietary supplement and pharmaceutical auxiliary material standards.
Our TUDCA is synthesized through advanced biotechnological amidation and repeated recrystallization purification. Standard specification: ≥98% HPLC white crystalline powder, low impurity content, strictly controlled heavy metals and residual solvents.
TEST REPORT
The Differences Between Tauroursodeoxycholic Acid and Ursodeoxycholic Acid
From a chemical structural perspective, tauroursodeoxycholic acid is a compound formed by the conjugation of ursodeoxycholic acid with taurine. This analogy likens ursodeoxycholic acid to a "rough diamond," while tauroursodeoxycholic acid represents a "finished piece of jewelry"—one that has undergone meticulous processing and setting. The structural differences between the two fundamentally determine their distinct subsequent functions.
In terms of mechanism of action, ursodeoxycholic acid primarily achieves the dissolution of cholesterol gallstones by inhibiting the intestinal reabsorption of cholesterol and reducing the saturation of cholesterol within the bile. Tauroursodeoxycholic acid not only retains some of the therapeutic properties of ursodeoxycholic acid but also excels in regulating bile acid metabolism and enhancing bile fluidity. It acts much like introducing additional "vitality factors" into the "river" of bile, thereby facilitating a smoother flow and mitigating the risk of bile stasis.
What are the benefits of tauroursodeoxycholic acid ?
Dissolving Cholesterol Gallstones
It increases the bile acid content in bile, reduces cholesterol saturation, and promotes the gradual dissolution of cholesterol gallstones.
Improving Cholestasis
It promotes bile secretion and excretion, reduces bile accumulation in the liver, and protects liver cells from damage caused by toxic bile acids. It is used to treat cholestatic liver diseases such as primary biliary cholangitis.
Cytoprotective Effects
It has anti-inflammatory, antioxidant, and anti-apoptotic effects, reducing cellular stress and damage, and has potential protective effects against neurodegenerative and cardiovascular diseases.
Pharmacological Effects
By promoting the secretion and flow of bile and increasing the concentration of bile salts within it, this mechanism reduces the deposition of cholesterol in the bile. This helps prevent the formation of gallstones and alleviates the symptoms of biliary tract diseases, such as cholecystitis and gallstones.
Research on Tauroursodeoxycholic Acid in Pets
1. Tauroursodeoxycholic acid can improve digestion and absorption in pets. Bile Acid Secretion: It stimulates the liver to synthesize primary bile acids in dogs and cats, enhancing the emulsification of dietary fat and improving intestinal absorption of lipids (including triglycerides and cholesterol) and fat-soluble vitamins (A/D/E/K). Pancreatic Lipase Activation: By regulating the intestinal alkaline environment, it significantly increases pancreatic lipase activity (canine studies have shown that lipolysis can increase by 12%-18%).
2. In terms of hepatobiliary protection, it reduces the accumulation of toxic bile acids (such as lithocholic acid) in canine and cat hepatocytes by downregulating the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, thereby alleviating cholestasis. Hepatocyte Repair: It inhibits hepatocyte apoptosis by activating the PI3K/Akt signaling pathway (clinical data show that after four weeks of treatment, ALT levels in cats with fatty liver decreased by an average of 43%).
3. Improve intestinal function and anti-inflammatory effects: Targeting the farnesoid X receptor (FXR), inhibiting the nuclear factor kappa B (NF-κB) pathway, and reducing the release of intestinal pro-inflammatory factors IL-6 and TNF-α. Mucosal barrier repair: Increasing the expression of tight junction proteins (ZO-1, occludin) and reducing the increased intestinal mucosal permeability caused by oxidative stress.
FAQ
Q: What certifications can you provide?
A: We hold GMP, ISO, HACCP, HALAL, KOSHER, FDA certificates, and support OEM private label customization.
Q: What specifications do you supply?
A: HPLC ≥98% high-purity Tauroursodeoxycholic Acid. Each batch is accompanied by official COA and third-party test documents.
Q: Product highlights?
A: Optimized synthesis & purification process, low impurity and solvent residue, stable purity across batches, high safety compliance for premium liver health supplements.
Q: Storage & shelf life?
Shelf life: 24 months. Keep sealed tightly, store in a cool, dry, dark environment below 25°C; refrigeration is recommended for long-term storage, avoid high temperature and direct light to prevent degradation.
Q: MOQ & delivery cycle?
A: MOQ can be negotiated according to order volume. Production period: 10–20 working days.
Q: After-sales support?
A: Formula matching guidance for liver protection and anti-aging supplements; return and exchange policy for qualified quality issues.
Email: sales@sxytbio.com
WhatsApp/phone: +86 17782577059
Office Add: No.801, Building 3, Dahua Shuzhi Industrial Park, Tiangu 6th Road, Yanta District, Xi 'an, Shaanxi, China