SAM 99% S-adenosyl Methionine CAS 485-80-3
What is S-Adenosyl Methionine (SAMe/SAM)?
YTBIO S-Adenosyl Methionine (SAMe/SAM) is a 99% pure, highly stable bioactive ingredient widely used in liver health and functional nutrition. SAMe is not a foreign chemical substance, but an important metabolic molecule naturally present in every cell of the human body. It is synthesized in the body from the amino acid methionine and ATP, participating in more than 40 key biochemical reactions and is considered a core component for maintaining cell vitality, metabolic balance, and tissue repair. YTBIO provides high-purity, highly consistent SAMe raw materials through a rigorous raw material screening and quality control system, offering reliable support for your nutritional supplements and health product formulations.
Why Choose YTBIO S-Adenosyl Methionine (SAM-e)？
We own our factory with over 12 years of experience supplying high-stability active amino acid derivative raw materials for mood balance, liver detox and joint health dietary supplements. Our production workshop complies with strict cGMP standards, equipped with full global certifications: cGMP, FSSC22000, BRC, HACCP, HALAL, KOSHER, ISO9001 & ISO22000, fully meeting international food and supplement safety specifications.
Our S-Adenosyl Methionine adopts advanced enzymatic synthesis and special stabilized salt technology (SAM-e disulfate tosylate), standard specification 1,4-butanedisulfonate salt, content 99% HPLC off-white crystalline powder, effectively prevent oxidation and degradation during storage and processing.
CERTIFICATE OF ANALYSIS
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ITEM |
STANDARD |
TEST RESULT |
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|
S-adenosyl Methionine |
95.0%-103% |
99.3% |
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Physical & Chemical |
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Appearance |
White to off-white powder |
Complies |
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PH |
1.0-2.0 |
1.2 |
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Loss on Drying |
≤3.0% |
1.0% |
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|
Ash |
≤0.5% |
Complies |
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|
Heavy Metal |
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Total Heavy Metals |
≤10ppm |
<10ppm |
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As |
≤2.0ppm |
<2.0ppm |
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Pb |
≤2.0ppm |
<2.0ppm |
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Cd |
≤0.5ppm |
<0.5ppm |
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Microbiological Test |
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Total Plate Count |
≤1,000cfu/g |
<10cfu/g |
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Mold and Yeast |
≤100cfu/g |
<10cfu/g |
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E.Coli |
≤10cfu/g |
<0.3cfu/g |
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|
Salmonella |
Negative |
Negative |
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Staphylococcus |
Negative |
Negative |
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Conclusion |
Conform with specification |
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Storage |
Store in cool and dry places. Keep away from strong light and heat |
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Packing |
By 25kgs/Drum, inner by double plastic bag |
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Shelf Life |
24 months under the above condition,and in it’s original package |
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Why is S-Adenosyl Methionine so important?
SAMe's uniqueness lies in its ability to fundamentally influence cellular function through three core mechanisms, with the liver being one of the most direct and benefiting target organs. When SAMe levels are sufficient in the body, liver cells can better perform detoxification, metabolism, and repair.
SAMe's Three Core Mechanisms of Action
1. Methyl Donor Function:
SAMe is the most important methyl donor in the human body. It participates in phospholipid synthesis, helping to maintain the healthy structure of cell membranes.
Importance to the Liver:
Improves hepatocyte membrane fluidity
Activates key enzyme systems such as the sodium-potassium pump
Promotes normal bile formation and flow
Supports bile metabolism at its source, helping to alleviate intrahepatic cholestasis
2. Antioxidant and Detoxification Support
SAMe is an important precursor for the synthesis of glutathione (GSH), a core antioxidant and detoxification molecule in the human body.
Importance to the Liver:
Enhancing the antioxidant capacity of hepatocytes
Neutralizing free radicals and toxic metabolites
Reduce oxidative stress damage to hepatocytes
3.Cell Repair and Anti-inflammatory Support
SAMe participates in polyamine synthesis, supporting cell proliferation and differentiation.
Importance to the Liver:
Promoting the regeneration of healthy hepatocytes
Repairing damaged liver tissue
Helping regulate inflammatory responses
Conclusion:
When SAMe levels decrease in the body, the risk of intrahepatic cholestasis, abnormal liver function, inflammation, and oxidative damage increases significantly, potentially driving liver fibrosis and even cirrhosis.
Exogenous SAMe supplementation is a scientific approach that systematically supports liver function recovery from the metabolic root cause.
Main Application Areas of S-Adenosyl Methionine
High-purity S-adenosylmethionine (SAMe), with its well-defined biological activity and mature applications, has become a trusted raw material in the global health industry.
1. Pharmaceuticals and Clinical Nutrition
SAMe is included in prescription or clinical nutrition systems in many countries worldwide, especially for adjunctive treatment and nutritional support of liver diseases. 99% high-purity SAMe meets the high standards required for medical foods and specific clinical nutrition programs.
2. Dietary Supplements
SAMe is widely used in various dietary supplement products, including:
Single-ingredient liver-protecting or mood-supporting supplements
Combined liver-protecting, joint health, or mood-regulating formulas
High-end comprehensive nutrition product lines (such as tablets, capsules, enteric-coated preparations, etc.)
3. Functional Foods
SAMe is increasingly being applied to food systems targeting specific health needs, such as:
Functional foods for liver protection, joint maintenance, or mood balance
Special dietary products for middle-aged and elderly nutrition, sports recovery, etc.
Modern health food development
4. Mood and Neurological Health Products
SAMe has become a classic ingredient in mood health products, suitable for:
Mood regulation and stress management supplements
Cognitive health and neurological support products
5. Sports Nutrition Products
Joint Health Complex Formulas (especially for middle-aged and elderly people and athletes)
Post-exercise Recovery and Inflammation Management Nutritional Products
Bone and Connective Tissue Health Support Products
FAQ
Q: What certifications can you offer?
A: We own GMP, ISO, HACCP, HALAL, KOSHER, FDA certificates, support OEM private label customization.
Q: What specifications of SAM-e do you supply?
A: Stabilized 1,4-butanedisulfonate SAM-e. Each batch attached COA and third-party test reports.
Q: Product highlights?
A: Bio-fermentation source, low-temperature extraction to retain activity, stable disulfonate salt not easy to degrade, triple effects for mood, liver and joints.
Q: Storage & shelf life?
Shelf life: 24 months. Seal tightly, store under cool dry dark environment (2–8°C cold storage recommended), avoid high temperature and light to prevent activity decline.
Q: MOQ, sample policy & delivery cycle?
A: Standard bulk MOQ 25kg, free samples with freight collected. Production cycle 7–15 working days.
Q: After-sales support?
A: Formula matching guidance for liver & mental health supplements;
WS : +86 17782577059