Factory Supply 99% L-Citrulline Powder CAS 372-75-8
L-Citrulline: Product Introduction
L-citrulline is an α-amino acid widely found naturally in cucurbitaceous plants such as watermelon and winter melon. It is a non-protein amino acid. In the human body, citrulline can be synthesized from ornithine via the urea cycle, or it can be synthesized in the intestines from glutamine. Approximately 13% of glutamine ingested in the intestines is converted into citrulline. Citrulline plays a crucial role in the body's metabolism. It is not only an important intermediate in the urea cycle, responsible for converting toxic ammonia produced by protein metabolism into non-toxic urea for excretion, but it also participates in regulating muscle protein synthesis, immune responses, and antioxidant defense. As a functional amino acid, citrulline has been widely used in the pharmaceutical, health product, and food industries.
Why Choose YTBIO L‑Citrulline?
We own our factory with over 12 years of experience supplying high‑grade amino acid raw materials for functional food and dietary supplement industry. Our full production line holds complete international certifications: cGMP, FSSC22000, BRC, HACCP, HALAL, KOSHER, ISO9001 & ISO22000, fully compliant with global health product safety standards.
Our L‑Citrulline is produced by advanced microbial fermentation technology. White crystalline powder, stable L‑isomer content, low impurity profile, consistent batch‑to‑batch quality.

Health Benefits
Urea Cycle and Detoxification
L-citrulline participates in the body's urea cycle. Daily protein metabolism produces excess ammonia, which citrulline converts into urea and excretes. This is crucial for maintaining the body's acid-base balance and eliminating toxic metabolic waste. Especially during exercise, muscle ammonia production increases; L-citrulline helps remove ammonia through the urea cycle, thus reducing fatigue.
Cardiovascular Protection
Supplementing with L-citrulline can increase arginine levels in the blood, promote nitric oxide production, help improve vascular endothelial function, and lower blood pressure.

Muscle Regulation
L-citrulline not only aids in muscle repair and regeneration but also promotes muscle protein synthesis, playing a positive role in maintaining muscle mass and improving athletic performance.
Immune Regulation and Anti-inflammatory Effects
L-citrulline also plays a role in the immune system. It can promote the proliferation and function of immune cells, enhancing immunity. In addition, L-citrulline possesses certain anti-inflammatory and antioxidant properties, reducing the release of inflammatory cytokines and protecting cells from oxidative stress damage.

Anti-aging effects
Recent scientific research has found that L-citrulline levels decline significantly with age and are associated with age-related metabolic disorders. L-citrulline supplementation has been shown to reduce cellular senescence, prevent DNA damage, regulate cellular metabolism, and alleviate chronic inflammation.
Application Areas Overview
Sports Nutrition
Enhancing Athletic Performance: Citrulline supplementation can improve exercise endurance, enhance muscle strength, and reduce post-exercise muscle soreness and fatigue. It is widely used in sports nutrition supplements.
Beauty & Skincare
Antioxidant and Anti-aging: Citrulline has antioxidant properties, scavenging free radicals, protecting cells from oxidative damage, and delaying skin aging. It is commonly used in high-end skincare products and masks, helping to reduce wrinkles and improve skin texture.
Food & Beverage
Functional Food Additive: As a natural amino acid, citrulline can be added to beverages, solid beverages, chewable tablets, and other foods to provide health benefits such as enhancing immunity and improving digestive function.
Pharmaceuticals & Healthcare
Cardiovascular Health Ingredient: By generating nitric oxide, it helps dilate blood vessels and reduce peripheral resistance, making it suitable for improving cardiovascular microcirculation in middle-aged and elderly individuals. It is an important ingredient in antihypertensive and heart-protective health products.
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FAQ
Q: What test method is used for L‑Citrulline assay?
A: Detected by HPLC, related amino acid impurities are strictly controlled simultaneously.
Q: How is the solubility performance of L‑Citrulline?
A: It dissolves well in water. Slight heating can accelerate dissolving speed, insoluble in most organic solvents.
Q: Can you provide customized specifications?
A: Yes, particle size and mesh grade can be adjusted according to customer formulation requirements.
Q: Will L‑Citrulline absorb moisture during storage?
A: This material is slightly hygroscopic. Keep package tightly sealed, avoid high‑humidity environment to prevent caking.
Q: Which quality indexes are strictly controlled?
A: Purity, optical rotation, heavy metals and microbial items are strictly controlled to meet food‑grade amino acid standards.
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